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The neurologic phenotype in SCA8 BAC growth although not BAC Regulate lines demonstrated the pathogenicity with the (CTG-CAG)n expansion. What's more, the expression of noncoding (CUG)n enlargement ATXN8OS transcripts and the discovery of intranuclear polyglutamine inclusions instructed that SCA8 pathogenesis consists of poisonous achieve-of-perfor